Utilization of S-adenosylmethionine by micro-organisms.

Polyenylphosphatidylcholine corrects the alcohol-induced hepatic oxidative stress by restoring s-adenosylmethionine.

AIMS Since the late stages of alcoholic liver injury are associated with decreased activity of methionine adenosyltransferase (MAT), we wondered whether this already occurs at the early stages and what is the mechanism involved. METHODS Sprague-Dawley rats (n = 32) were pair-fed ethanol (36% of energy) or isocaloric carbohydrates (control) in Lieber-DeCarli liquid diets, with or without polye...

Boron deprivation decreases liver S-adenosylmethionine and spermidine and increases plasma homocysteine and cysteine in rats.

Two experiments were conducted with weanling Sprague-Dawley rats to determine whether changes in S-adenosylmethionine utilization or metabolism contribute to the diverse responses to boron deprivation. In both experiments, four treatment groups of 15 male rats were fed ground corn-casein based diets that contained an average of 0.05 mg (experiment 1) or 0.15 mg (experiment 2) boron/kg. In exper...

Effect of Low Frequency Low-Level Infra-Red Diode Laser Therapy on Third Degree Burn Healing in Rats Skin

Purpose: The aim of present investigation was to evaluate low frequency low-level infra red diode laser therapy for a third degree burn healing in rats skin.Materials and Methods: 36 rats were divided into groups one and two. On day zero three third degree burns were made on the dorsum of each rat by steam. In group one ,first burn were exposed to a 80 Hz –pulsed 890 nm infra red diode laser wi...

The utilization of pyridine by micro-organisms.

Characterization of a Novel Putative S-Adenosylmethionine Decarboxylase-Like Protein from Leishmania donovani

In addition to the S-adenosylmethionine decarboxylase (AD) present in all organisms, trypanosomatids including Leishmania spp. possess an additional copy, annotated as the putative S-adenosylmethionine decarboxylase-like proenzyme (ADL). Phylogenetic analysis confirms that ADL is unique to trypanosomatids and has several unique features such as lack of autocatalytic cleavage and a distinct evol...